Meta-analysis shows: HAP is as effective as fluoride in caries prophylaxis

Numerous scientific publications confirm the effect of hydroxyapatite (HAP) in oral care. However, a systematic literature review and meta-analysis of the study data are always necessary to verify the evidence of efficacy of an application. This Canadian-German collaboration is the first scientific evaluation of all studies on HAP of this kind with respect to caries prophylaxis.

How effective is hydroxyapatite in caries prophylaxis?

A systematic literaturereview in 5 databases, as well as their structured analysis – based on the highest scientific standards, was performed. The clinical studies available were examined for bias. Subsequently, the data were summarized in a meta-analysis.

A total of 291 studies were identified that investigated HAP in the context of oral care. Three recent clinical trials were used for the meta-analysis from this selection. Here it was found that HAP reduces caries by 17%. Since HAP was compared to fluoride in terms of caries-protective effect in a majority of the studies, a key message of this scientific review is: HAP is (at least) as effective as fluoride in caries prophylaxis.

HAP is effective in caries prophylaxis. Oral care products containing HAP provide an effective alternative to products containing fluoride – especially for children and all those who do not want fluoride in their oral care products.

The publication of the study can be found here.

_{Source:  Limeback, H., Enax, J. & Meyer, F. Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis. Can J Dent Hyg 55, 148-159 (2021).}